Key result
Metabolic syndrome was significantly associated with an increased prevalence of carotid plaque (OR 1.25), including both stable and unstable plaques, in a general Chinese population.
Why the study?
Does metabolic syndrome increase the prevalence of stable and unstable carotid plaque in a general Chinese population?
Cross-Sectional (n=5,393)
Does metabolic syndrome increase the prevalence of stable and unstable carotid plaque in a general Chinese population?
Metabolic syndrome and its individual components are significantly associated with an increased prevalence of both stable and unstable carotid plaques in the general Chinese population.
Answers are grounded in this paper and cite their sources.
May aid risk stratification; leaves open whether intervention reduces plaque progression.
Few studies have investigated the prevalence of carotid plaque with different stability in Chinese. As is well known, carotid atherosclerosis is tightly associated with metabolic syndrome (MetS); however, the data about the association between the presence of carotid plaque with different stability and MetS was limited. The aim of our study was to investigate the prevalence of carotid plaque with different stability and its potential association with MetS in general Chinese population.The Asymptomatic Polyvascular Abnormalities Community study is a community-based study to investigate the epidemiology of asymptomatic polyvascular abnormalities in Chinese adults. A total of 5393 participants were finally eligible and included in this study. The carotid plaque and its stability were assessed using ultrasonography. The MetS was defined using the criteria from US National Cholesterol Education Program-Adult Treatment Panel III. Data were analyzed with multivariate logistic regression models.Of the 5393 subjects, 1397 (25.9%) participants had stable carotid plaque, 1518 (28.1%) had unstable carotid plaque in participants, and 1456 (27.0%) had a MetS. MetS was, respectively, significantly associated with the prevalence of carotid plaque (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.07, 1.47), stable carotid plaque (OR: 1.23; 95% CI: 1.02,1.48), and unstable carotid plaque (OR: 1.27; 95% CI: 1.03,1.56) after adjusting for age, gender, level of education, income, smoking, drinking, physical activity, body mass index, low-density lipoprotein, and high-sensitivity C-reactive protein. With the number of MetS components, the prevalence of carotid plaque, stable carotid plaque, and unstable carotid plaque significantly increased (P for trend <0.0001), respectively.In summary, the prevalence of carotid plaque was 54.1%, stable carotid plaque was 25.9%, and unstable carotid plaque was 28.1%. Our study revealed that the prevalence of carotid plaque, stable carotid plaque, and unstable carotid plaque was, respectively, significantly associated with MetS in the general population.
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Wang et al. (2016) conducted a cross-sectional in Metabolic syndrome and carotid plaque (n=5,393). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Prevalence of carotid plaque (OR 1.25, 95% CI 1.07-1.47, p=<0.01). Metabolic syndrome was significantly associated with an increased prevalence of carotid plaque (OR 1.25), including both stable and unstable plaques, in a general Chinese population.
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