December 1, 1986Critical Care Medicine
Continuous pump-driven hemofiltration associated with a decline in alpha-atrial natriuretic peptide
Why the study?
Does continuous veno-venous hemofiltration reduce alpha-atrial natriuretic peptide levels in patients with volume-expansion?
Population
8 patients with volume-expansion due to different diseases
Design
Case_series
Authors
Discussion
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Member takes
Implication
Alpha-ANP may track volume changes with CVVH; single-case observation leaves open prospective validation before clinical use.
Structured PICO
Does continuous veno-venous hemofiltration reduce alpha-atrial natriuretic peptide levels in patients with volume-expansion?
P
Population
8 patients with volume-expansion due to different diseases
I
Intervention
Continuous veno-venous hemofiltration for fluid removal
O
Outcome
Alpha-atrial natriuretic peptide (ANP) levels measured by radioimmunoassay in the right atrium, pulmonary artery, radial artery, and superior vena cava plasmasurrogate
Alpha-ANP levels decrease following fluid removal by continuous veno-venous hemofiltration and correlate with pulmonary capillary wedge pressure, suggesting its utility as a marker of volume status in critically ill patients.
Cite This Study
Pacher et al. (1986) studied this question.