Key result
Evening administration of antihypertensive medication did not significantly reduce vascular death, nonfatal myocardial infarction, or nonfatal stroke compared to morning administration (HR 0.95).
Why the study?
It was unclear whether taking blood pressure medication at night versus in the morning results in fewer cardiovascular events.
Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?
Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?
Hazard Ratio: 0.95 (95% CI 0.83–1.1)
Absolute Event Rate: 0.69% vs 0.72%
p-value: p=.53
Taking antihypertensive medications at night does not provide cardiovascular benefits over morning administration, and dosing time should be individualized to maximize patient adherence.
Antihypertensive timing does not affect cardiovascular outcomes; challenges bedtime superiority amid contradictory RCTs.
PROBABLY NOT. In patients who have hypertension, the timing of administration of antihypertensive medications does not appear to impact cardiovascular outcomes (strength of recommendation: B; contradictory randomized controlled trials).
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Robert Martin (2023) conducted a review in Hypertension (n=21,104). Evening administration of antihypertensive medication vs. Morning administration of antihypertensive medication was evaluated on Composite of vascular death, nonfatal myocardial infarction, or nonfatal stroke (HR 0.95, 95% CI 0.83-1.10, p=.53). Evening administration of antihypertensive medication did not significantly reduce vascular death, nonfatal myocardial infarction, or nonfatal stroke compared to morning administration (HR 0.95).
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