March 2, 1999Proceedings of the National Academy of Sciences

Ca 2+ -induced inhibition of the cardiac Ca 2+ channel depends on calmodulin

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Population

alpha1C voltage-gated Ca2+ channels

Design

Preclinical

Authors

NQNa QinTianjin University of Technology RORiccardo OlceseUniversity of California, Los Angeles MBMichael BransbyUniversity of California, Los Angeles

Discussion

Member takes

Implication

Provides mechanistic insight into cardiac Ca channel inhibition; leaves open whether IQ motif targeting offers therapeutic potential in humans.

Structured PICO

Population

alpha1C voltage-gated Ca2+ channels

Intervention

Disruption of the IQ motif binding activity

Outcome

Ca2+ inhibition of the channelsurrogate

The study demonstrates that calmodulin binding to the IQ motif is essential for Ca2+-induced inhibition of cardiac alpha1C voltage-gated Ca2+ channels.

Cite This Study

Qin et al. (1999) studied this question.

synapsesocial.com/papers/6a733f5064decaab472c221a https://doi.org/10.1073/pnas.96.5.2435

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Implication

Provides mechanistic insight into cardiac Ca channel inhibition; leaves open whether IQ motif targeting offers therapeutic potential in humans.

Ca 2+ -induced inhibition of the cardiac Ca 2+ channel depends on calmodulin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ca 2+ -induced inhibition of the cardiac Ca 2+ channel depends on calmodulin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider