Population
Chimeric Ca2+ channels derived from parental alpha 1C and alpha 1E channels
Comparison
Donation of the alpha 1C EF-hand region to the… vs Parental alpha 1E channel
Design
Preclinical
Authors
Loading...
EF-hand motif is required for L-type Ca2+ channel inactivation; extends molecular mapping but leaves open in vivo cardiac relevance.
The EF-hand motif on the alpha 1C subunit is the essential structural determinant initiating Ca2+-sensitive inactivation of L-type Ca2+ channels.
Leon et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: