March 17, 1998Proceedings of the National Academy of Sciences

Ca 2+ -sensitive inactivation of L-type Ca 2+ channels depends on multiple cytoplasmic amino acid sequences of the α 1C subunit

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Population

Human alpha1C subunit of L-type Ca2+ channels (preclinical model)

Design

Preclinical

Authors

RZRoger D. ZühlkeSwissmedic HRH. RéuterUniversity of Cologne

Discussion

Member takes

Implication

Does not yet guide clinical Ca channel therapies; leaves open structural targets for future mechanistic and translational studies.

Structured PICO

Population

Human alpha1C subunit of L-type Ca2+ channels (preclinical model)

Intervention

Truncation mutations (systematic deletion of an EF-hand motif and sequences in a segment of 80 amino acids in the carboxyl-terminal tail)

Outcome

Rate and Ca2+ dependence of inactivation of currentssurrogate

Ca2+-dependent inactivation of L-type Ca2+ channels is a cooperative process involving multiple specific amino acid sequences in the cytoplasmic segments of the alpha1C subunit.

Cite This Study

Zühlke et al. (1998) studied this question.

synapsesocial.com/papers/6a75d18bb5de85d41819cb1e https://doi.org/10.1073/pnas.95.6.3287

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Ca 2+ -sensitive inactivation of L-type Ca 2+ channels depends on multiple cytoplasmic amino acid sequences of the α 1C subunit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ca 2+ -sensitive inactivation of L-type Ca 2+ channels depends on multiple cytoplasmic amino acid sequences of the α 1C subunit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider