Population
Xenopus oocytes expressing mutated L-type Ca2+ channels (alpha1C,77 and alpha1C,86 isoforms)
Comparison
Oligonucleotide-directed segment substitution vs Wild-type 'slow' alpha1C,77 channel and 'fast'…
Design
Preclinical
Authors
Loading...
No immediate clinical implications; leaves open human relevance of these motifs for Ca2+-dependent inactivation.
Motifs 1572-1576 and 1600-1604 of the alpha1C,77 L-type Ca2+ channel cooperatively determine its inactivation kinetics and are critical for Ca2+-dependent inactivation.
Soldatov et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: