Ontogenic appearance of Ca²⁺ channels characterized as binding sites for nitredipine during development of nervous, skeletal and cardiac muscle systems in the rat

T Kazazoglou; Annie Schmid‐Alliana; Jean‐François Renaud; Michel Lazdunski

doi:10.1016/0014-5793(83)80022-2

November 28, 1983FEBS Letters

Ontogenic appearance of Ca²⁺ channels characterized as binding sites for nitredipine during development of nervous, skeletal and cardiac muscle systems in the rat

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Key Points

To characterize the developmental appearance and binding properties of calcium channels in nervous, skeletal, and cardiac muscle tissues across fetal and postnatal stages in rats.
Measured specific binding of the calcium channel antagonist nitrendipine in rat brain without cerebellum, cerebellum, skeletal muscle, and cardiac muscle.
Evaluated changes in receptor density and receptor-ligand dissociation constant (Kd) from fetal life through postnatal development.
Nitrendipine receptor density is low at the fetal stage and increases markedly during postnatal development across all four examined tissues.
The developmental time course of receptor accumulation differs distinctly among brain, cerebellum, skeletal muscle, and cardiac muscle.
Receptor-ligand dissociation constant (Kd) shows no significant change across the developmental period in any of the tissues.

Structured PICO

P

Population

Rat tissues (brain without cerebellum, cerebellum, skeletal muscle, and cardiac muscle) during fetal and post-natal development

I

Intervention

Measurement of nitrendipine binding sites (Ca2+ channels)

C

Comparator

Fetal versus post-natal developmental stages

O

Outcome

Number of nitrendipine receptors and receptor ligand dissociation constant (Kd)surrogate

Nitrendipine binding sites (Ca2+ channels) increase drastically during post-natal development in rat excitable tissues, including cardiac muscle, without changes in binding affinity.

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Implication

Postnatal Ca2+ channel upregulation in rat heart may influence developmental drug sensitivity; leaves open applicability to human perinatal cardiology.

Abstract

The appearance of specific receptors for the Ca2+ channel antagonist nitrendipine has been followed during the fetal and post-natal development of rat brain without cerebellum, cerebellum, skeletal muscle and cardiac muscle. The number of nitrendipine receptors is low at the fetal stage and increases drastically during post-natal development of brain, cerebellum, skeletal muscle and cardiac muscle. The time course of this increase is different for each type of tissue studied. No significant change in receptor ligand dissociation constant (Kd) can be detected over the development period studied. The results are discussed in relation with the known properties of the differentiation process in the four types of excitable tissues studied.

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Cite This Study

Kazazoglou et al. (1983) studied this question.

synapsesocial.com/papers/6a733f6a9114ba2b47c23a18 https://doi.org/10.1016/0014-5793(83)80022-2

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Ontogenic appearance of Ca²⁺ channels characterized as binding sites for nitredipine during development of nervous, skeletal and cardiac muscle systems in the rat

Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Ontogenic appearance of Ca²⁺ channels characterized as binding sites for nitredipine during development of nervous, skeletal and cardiac muscle systems in the rat

Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

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