Key result
Placebo frequently normalizes blood pressure in mild hypertension while provoking substantial symptomatic adverse effects.
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In essential hypertension, the blood pressure is variable, with large changes occurring in response to variations in physical and emotional stimuli. Patients given placebo tablets often have short-lived decreases in blood pressure. Placebo-controlled studies are essential for the proper evaluation of antihypertensive drugs. In longer term studies in mild hypertension, many patients given placebos have substantial decreases in blood pressure, often to normal levels, a finding that makes a period of observation desirable before commencing active treatment. Patients given placebos also have a high incidence of symptomatic side effects.
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A. E. Doyle (1983) conducted a review in Essential hypertension. Placebo treatment vs. Active antihypertensive drugs was evaluated on Blood pressure reduction and symptomatic side effects. Placebo treatment in mild hypertension often produces substantial blood pressure decreases to normal levels along with a high incidence of symptomatic side effects.
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