Why the study?
A non-canonical pathway of the renin-angiotensin system in blood pressure control has been highlighted, prompting a reconsideration of the physiological roles of peptidases involved in this pathway.
This paper reviews the physiological roles of angiotensinases in the non-canonical renin-angiotensin system pathway in placental tissue and blood.
Re-evaluating angiotensinase roles in non-canonical RAS leaves open their relevance to placental hypertension; prospective studies needed before clinical consideration.
The existence of a non-canonical pathway of renin-angiotensin system in the blood pressure control system has been highlighted over the past three decades. The enzymes involved in this pathway include a series of angiotensinases such as neprilysin (NEP), aminopeptidase A (APA), carboxypeptidase, and angiotensin converting enzyme 2. The physiological roles of these peptidases have been reconsidered in this study, based on the publications of other research groups and the results from our previous study, regarding the liberation of constituent amino acids from angiotensin II by placenta tissue and blood serum, respectively.
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Mizutani et al. (2023) studied this question.
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