Key result
COPD is linked to ~3-fold higher incidence of new-onset heart failure.
Why the study?
The study was conducted to estimate the incidence of ischaemic heart disease, atrial fibrillation, and heart failure in community patients with or without chronic obstructive pulmonary disease.
Does chronic obstructive pulmonary disease (COPD) increase the incidence of new-onset ischaemic heart disease, atrial fibrillation, and heart failure in community patients aged 40-80 years compared with individuals without COPD?
Cohort (n=143,251)
Yes
Does chronic obstructive pulmonary disease (COPD) increase the incidence of new-onset ischaemic heart disease, atrial fibrillation, and heart failure in community patients aged 40-80 years compared with individuals without COPD?
Answers are grounded in this paper and cite their sources.
Community patients with COPD have a substantially higher incidence of new-onset heart failure (nearly threefold), ischaemic heart disease, and atrial fibrillation than individuals without COPD, with the largest relative risk increases occurring in younger patients and females, supporting proactive cardiovascular screening in COPD.
OBJECTIVE: To estimate the incidence of ischaemic heart disease, atrial fibrillation and heart failure in community patients with or without chronic obstructive pulmonary disease (COPD). METHODS: For this population-based study, we used primary care data of the Julius General Practitioners' Network. Eligible participants were aged 40-80 years old and contributed data between January 2014 and February 2019. Participants were divided into groups according to COPD status and were followed up for new ischaemic heart disease, atrial fibrillation and/or heart failure. Age-specific and sex-specific incidence and incidence rate ratios were calculated for patients with and without COPD. RESULTS: Mean follow-up was 3.9 years, 6223 patients were included in the COPD group, and 137 028 individuals in the background group without COPD. Incidence rates of all three heart diseases increased with age and were higher in males, independent of presence of COPD. Incidence rate ratios for patients with COPD, adjusted for age and sex, were 1.69 (95% CI 1.49 to 1.92) for ischaemic heart disease, 1.56 (95% CI 1.38 to 1.77) for atrial fibrillation and 2.96 (95% CI 2.58 to 3.40) for heart failure. CONCLUSION: The incidence of all major cardiovascular diseases is higher in patients with COPD, with the highest incidence rate ratio observed for heart failure.
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Groenewegen et al. (2022) conducted a cohort in Chronic obstructive pulmonary disease (COPD) and new-onset cardiovascular diseases (ischaemic heart disease, atrial fibrillation, heart failure) (n=143,251). Chronic obstructive pulmonary disease (COPD) vs. Individuals without COPD (background group) was evaluated on New-onset heart failure (alongside ischaemic heart disease and atrial fibrillation) (IRR 2.96, 95% CI 2.58 to 3.40). COPD was associated with higher age- and sex-adjusted incidence of heart failure (IRR 2.96), ischaemic heart disease (IRR 1.69), and atrial fibrillation (IRR 1.56) compared to no COPD.
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