Key result
A multimarker panel including high-sensitivity troponins, BNP, NT-proBNP, and ST2 can be utilized for the accurate diagnosis, management, and prognosis of heart failure.
Why the study?
Does the use of novel biomarkers (BNP, NT-proBNP, ST2, troponins) improve the diagnosis, management, and prognosis of heart failure?
Does the use of novel biomarkers (BNP, NT-proBNP, ST2, troponins) improve the diagnosis, management, and prognosis of heart failure?
Highlights the utility of a multimarker panel including natriuretic peptides, troponins, and ST2 for comprehensive heart failure management and risk stratification.
May support multimarker panels in heart failure; leaves open prospective validation before practice change.
PURPOSE OF REVIEW: Natriuretic peptides, high-sensitivity cardiac troponins, and suppression of tumorigenicity 2 are novel biomarkers that reflect the intricate pathophysiology of heart failure and can thus be used for the diagnosis, management, and prognosis of heart failure. RECENT FINDINGS: This review article describes the significance of B-type natriuretic peptide (BNP), N-terminal prohormone of BNP, ST2, and cardiac troponins. We outline their new roles in guiding the management of heart failure as well as strong prognostic indicators for adverse cardiovascular outcomes. SUMMARY: By recognizing the diagnostic and prognostic significance of these biomarkers, clinicians can utilize these biomarkers to more accurately evaluate and risk stratify patients. These markers can also be used to help guide the medical management of heart failure. The best approach for an accurate diagnosis, management, and prognosis of heart failure will likely involve a multimarker panel of biomarkers, which may include high-sensitivity troponins, BNP, N-terminal prohormone of BNP, and ST2.
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Ghashghaei et al. (2016) conducted a review in Heart failure. Biomarkers (BNP, NT-proBNP, ST2, cardiac troponins) was evaluated. A multimarker panel including high-sensitivity troponins, BNP, NT-proBNP, and ST2 can be utilized for the accurate diagnosis, management, and prognosis of heart failure.
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