October 1, 1995Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Patients With ApoE3 Deficiency (E2/2, E3/2, and E4/2) Who Manifest With Hyperlipidemia Have Increased Frequency of an Asn 291→Ser Mutation in the Human LPL Gene

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Why the study?

Does the Asn 291-->Ser mutation in the LPL gene predispose to hyperlipoproteinemia in patients with apoE2 genotypes?

Population

270 individuals, including 18 patients with type III hyperlipoproteinemia and apoE2/2 genotype, 22…

Comparison

Presence of Asn 291-->Ser mutation in the LPL gene vs Normolipidemic controls

Design

Case-control

Authors

HZHanfang ZhangBeijing Anzhen Hospital PRPaul W.A. ReymerLeiden University MLMing-Sun LiuAmsterdam UMC Location University of Amsterdam

Discussion

Member takes

Implication

May support LPL variant consideration in apoE2 dyslipidemia; hypothesis-generating and should not yet change practice.

Structured PICO

Does the Asn 291-->Ser mutation in the LPL gene predispose to hyperlipoproteinemia in patients with apoE2 genotypes?

Population

270 individuals, including 18 patients with type III hyperlipoproteinemia and apoE2/2 genotype, 22 hyperlipidemic E2 heterozygous patients (apoE3/2 and E4/2 genotype), and 230 normolipidemic controls.

Intervention

Presence of Asn 291-->Ser mutation in the LPL gene

Comparator

Normolipidemic controls

Outcome

Allele frequency of the Asn 291-->Ser mutation in the LPL genesurrogate

The Asn 291-->Ser mutation in the LPL gene is a significant predisposing factor for the expression of hyperlipidemia in patients with apoE2 genotypes.

Cite This Study

Zhang et al. (1995) studied this question.

synapsesocial.com/papers/6a73407c629d045705c675db https://doi.org/10.1161/01.atv.15.10.1695

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Patients With ApoE3 Deficiency (E2/2, E3/2, and E4/2) Who Manifest With Hyperlipidemia Have Increased Frequency of an Asn 291→Ser Mutation in the Human LPL Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Patients With ApoE3 Deficiency (E2/2, E3/2, and E4/2) Who Manifest With Hyperlipidemia Have Increased Frequency of an Asn 291→Ser Mutation in the Human LPL Gene

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider