July 3, 1995FEBS LettersOpen Access

The mutant Asn291 → Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin

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Population

COS1 cells and human fibroblasts expressing wild-type or Asn291-->Ser mutant human lipoprotein lipase

Comparison

Expression of Asn291-->Ser mutant human LPL vs Expression of wild-type (WT) human LPL

Design

Preclinical

Authors

RBRoser BuscàCentre National de la Recherche Scientifique JPJulia PeinadoUniversitat de Barcelona EVElisabeth VilellaInstitut Pere Mata

Discussion

Member takes

Implication

N291S may reduce LPL activity in hyperlipidemia; leaves open clinical relevance pending human validation.

Structured PICO

Population

COS1 cells and human fibroblasts expressing wild-type (WT) or Asn291-->Ser (N291S) mutant human lipoprotein lipase (LPL)

Intervention

Expression of Asn291-->Ser (N291S) mutant human LPL

Comparator

Expression of wild-type (WT) human LPL

Outcome

LPL specific activity, secretion, intracellular distribution, and heparin binding affinitysurrogate

The N291S mutation in human lipoprotein lipase reduces its catalytic activity without affecting heparin binding, providing a mechanistic explanation for hyperlipidemia in patients with this mutation.

Cite This Study

Buscà et al. (1995) studied this question.

synapsesocial.com/papers/6a82c1fce41271e79b8d60e9 https://doi.org/10.1016/0014-5793(95)00582-t

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The mutant Asn291 → Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The mutant Asn291 → Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider