Key result
T-type Ca2+ channel blockade with efonidipine or mibefradil improved survival and reduced arrhythmogenicity in mouse models of dilated cardiomyopathy and myocardial infarction.
Why the study?
Does T-type Ca2+ channel blockade prevent sudden death and reduce arrhythmogenicity in mouse models of heart failure and myocardial infarction?
Population
Cardiac-specific, dominant-negative form of neuron-restrictive silencer factor transgenic mice and mice with…
Comparison
Efonidipine, mibefradil, or R-isomer of… vs Nitrendipine and/or control
Design
Preclinical
Authors
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Hypothesis-generating in murine HF models; human trials required before considering T-type Ca2+ blockade for arrhythmia prevention.
Does T-type Ca2+ channel blockade prevent sudden death and reduce arrhythmogenicity in mouse models of heart failure and myocardial infarction?
T-type Ca2+ channel blockade improves survival and reduces arrhythmias in mouse models of dilated cardiomyopathy and myocardial infarction, suggesting a potential therapeutic approach for preventing sudden death in heart failure.
Kinoshita et al. (2009) studied Heart failure. T-type Ca2+ channel blockade (efonidipine, mibefradil) vs. Nitrendipine (selective L-type Ca2+ channel blocker) was evaluated on Survival and arrhythmogenicity. T-type Ca2+ channel blockade with efonidipine or mibefradil improved survival and reduced arrhythmogenicity in mouse models of dilated cardiomyopathy and myocardial infarction.
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