Effect estimate: IC50=0.43 µM for efonidipine, 0.89 µM for mibefradil, 1.91 µM for nifedipine
Efonidipine, a dihydropyridine analog, is an effective blocker of the cloned human cardiac T-type Ca2+ channel, with potency similar to or slightly higher than mibefradil.
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K et al. (2000) studied this question. Calcium channel antagonists (mibefradil, efonidipine, nifedipine) vs. Control conditions was evaluated on Inhibition of T-type Ca2+ channel current (IC50) (IC50=0.43 µM for efonidipine, 0.89 µM for mibefradil, 1.91 µM for nifedipine).
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