Key result
Mibefradil blocked T-type calcium currents with an IC50 of 0.1 microM and displayed voltage- and use-dependent inhibition of L-type calcium currents.
Why the study?
Does mibefradil inhibit T-type and L-type calcium channels in cardiac cells?
Population
Rat atrial and ventricular cells, human atrial cells, and rabbit sinoatrial cells
Design
Preclinical
Authors
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Hypothesis-generating for predominant L-type effects; leaves open human translation from animal cardiac cells.
Does mibefradil inhibit T-type and L-type calcium channels in cardiac cells?
Mibefradil's inhibition of L-type calcium channels is voltage- and use-dependent and has likely been underestimated, potentially accounting for most of its cardiovascular effects.
Leuranguer et al. (2001) studied this question. Mibefradil was evaluated on Inhibition of T-type and L-type Ca2+ currents (IC50). Mibefradil blocked T-type calcium currents with an IC50 of 0.1 microM and displayed voltage- and use-dependent inhibition of L-type calcium currents.
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