Why the study?
Does mibefradil reduce blood pressure and myogenic tone via T-type or L-type calcium channels in mice?
Does mibefradil reduce blood pressure and myogenic tone via T-type or L-type calcium channels in mice?
The antihypertensive and vasodilatory effects of mibefradil, previously thought to be mediated by T-type calcium channels, are actually mediated by the Cav1.2 L-type calcium channel.
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Mibefradil's BP effects may act via L-type rather than T-type channels in mice; challenges prior assumptions but leaves clinical translation open.
Moosmang et al. (2005) studied this question.
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