Why the study?
Does mibefradil prevent neointima formation after vascular injury in rats compared to amlodipine and verapamil?
Population
Rats with balloon-induced vascular injury
Comparison
Mibefradil (30 mg/kg) vs Equihypotensive doses of amlodipine and verapamil
Design
Preclinical
Follow-up
14 days
Authors
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Does not support clinical use to prevent restenosis; hypothesis-generating for T-type calcium channel blockade in vascular injury models.
Does mibefradil prevent neointima formation after vascular injury in rats compared to amlodipine and verapamil?
Mibefradil, a T-type calcium channel blocker, significantly reduces neointima formation after vascular injury in rats, unlike L-type blockers.
Schmitt et al. (1995) studied this question.
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