High-output heart failure from conditions like hyperthyroidism or cardiac beriberi should be considered as a reversible cause of pulmonary hypertension.
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Reversible PH after treating hyperthyroidism or beriberi may warrant targeted evaluation; case reports leave open prospective confirmation.
Two cases of high-output heart failure associated with pulmonary hypertension are presented. In a 32-year-old man with hyperthyroidism, pulmonary hypertension subsided after antithyroid therapy. Increased pulmonary blood flow and elevated left ventricular end-diastolic pressure were suspected as the causes of pulmonary hypertension. In a 51-year-old man with cardiac beriberi, the pulmonary hypertension improved after thiamine administration. We suspect that increased pulmonary blood flow, elevated left ventricular end-diastolic pressure, and probably pulmonary vasoconstriction were the causes of pulmonary hypertension. Thus, high-output heart failure should be considered as a possible cause of pulmonary hypertension and right ventricular failure.
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Okura et al. (1994) studied this question.
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