The Natural Occurrence of Antithyroid Compounds as a Cause of Simple Goiter

Article1 June 1949THE NATURAL OCCURRENCE OF ANTITHYROID COMPOUNDS AS A CAUSE OF SIMPLE GOITERE. B. ASTWOOD, M.D., F.A.C.P.E. B. ASTWOOD, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-6-1087 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs more is learned about the thyroid gland the more plausible is the concept that goiter is a compensatory enlargement consequent to some interference with normal thyroid function. The subject of continuing debate, however, relates to the relative importance of the numerous factors which are known to be or which are suspected of being concerned in thyroid hormone synthesis. While there can be no question of the fact that iodine is an essential dietary ingredient; and, while it is well established that iodine deficiency is a cause of simple goiter, there is reason to believe that goiter is not always...Bibliography1. SAINT-LAGER J: Études sur les causes du crétinisme et du goitre endémique, J.-B. Baillière et fils, 1867, Paris. Google Scholar2. MCCARRISON R: The problem of endemic goiter, Brit. Med. Jr., 1937, i, 29. CrossrefGoogle Scholar3. RIGGS D: Federation Proc., 1949, viii, 328. Google Scholar4. CHESNEYCLAWSONWEBSTER AMTAB: Endemic goiter in rabbits. I. Incidence and characteristics, Bull. Johns Hopkins Hosp., 1928, xliii, 261-277. WEBSTER, B., CLAWSON, T. A., and CHESNEY, A. M.: Endemic goiter in rabbits. II. Heat production in goitrous and non-goitrous animals, Bull. Johns Hopkins Hosp., 1928, xliii, 278-290. WEBSTER, B., and CHESNEY, A. M.: Endemic goiter in rabbits. III. Effect of administration of iodine, Bull. Johns Hopkins Hosp., 1928, xliii, 291. Google Scholar5. MARINEBAUMANNCIPRA DEJA: Studies on simple goiter produced by cabbage and other vegetables, Proc. Soc. Exper. Biol. and Med., 1929, xxvi, 822. CrossrefGoogle Scholar6. MARINEBAUMANNSPENCECIPRA DEJAWA: Further studies on the etiology of goiter with particular reference to the action of cyanides, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 772-775. CrossrefGoogle Scholar7. SPENCEWALKERSCOWEN AWFHEF: Studies on the experimental production of simple goitre, Biochem. Jr., 1933, xxvii, 1992. CrossrefGoogle Scholar8. MARINEBAUMANNWEBSTER DEJB: Occurrence of antigoitrogenic substances in plant juices, Proc. Soc. Exper. Biol. and Med., 1930, xxvii, 1029. CrossrefGoogle Scholar9. SPENCE AW: The effect of the administration of cyanides on the thyroid gland of chickens, Jr. Pharmacol. and Exper. Therap., 1933, xlviii, 327. Google Scholar10. MARINEBAUMANNSPENCECIPRA DEJAWA: Further studies on etiology of goiter with particular reference to the action of cyanides, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 772-775. CrossrefGoogle Scholar11. BARKER MH: The blood cyanates in the treatment of hypertension, Jr. Am. Med. Assoc., 1936, cvi, 762-767. CrossrefGoogle Scholar12. MCCARRISON R: Studies on goitre produced by cabbage, Ind. Jr. Med. Res., 1931, xviii, 1311. Google Scholar13. MCCARRISON R: A paper on food and goitre, Brit. Med. Jr., 1933, ii, 671. CrossrefGoogle Scholar14. MCCARRISON R: The goitrogenic action of soya-bean and ground nut, Ind. Jr. Med. Res., 1934, xxi, 179. Google Scholar15. HERCUSAITKEN CEHA: Miscellaneous studies on the iodine and goitre problem in New Zealand, Jr. Hyg., 1933, xxxiii, 55. CrossrefGoogle Scholar16. HERCUSPURVES CEHD: Studies on endemic and experimental goitre, Jr. Hyg., 1936, xxxvi, 182. CrossrefGoogle Scholar17. STINER O: Blutgifte als kropfnoxe, Mitt. a. d. Geb. d. Lebensmittelunt. u. Hyg., 1933, xxiv, 90-93. Google Scholar18. INDINA N: The action of plants of the Brassica class on the thyroid, Jr. Med. Kiev, 1940, x. Google Scholar19. KENNEDYPURVES THHD: Studies on experimental goitre. I. The effect of brassica seed diet on rats, Brit. Jr. Exper. Path., 1941, xxii, 241-244. Google Scholar20. BLUM F: Studien um Kropf problem. II. Verbreitung von Kropf noxen im Pflanzenreich und Empfanglichkeit des Tierreichs gegenuber der Schadigung, Schweiz. med. Wchnschr., 1942, lxx, 1301-1305, 1329-1333. Google Scholar21. GRIESBACH WE: Studies on experimental goitre. II. Changes in the anterior pituitary of the rat, produced by brassica seed diet, Brit. Jr. Exper. Path., 1941, xxii, 245-249. Google Scholar22. GRIESBACHKENNEDYPURVES WETHHD: Studies on experimental goitre. III. The effect of goitrogenic diet on hypophysectomized rats, Brit. Jr. Exper. Path., 1941, xxii, 249-254. Google Scholar23. PURVES HD: Studies on experimental goitre. IV. The effect of diïodotyrosine on the goitrogenic action of brassica seeds, Brit. Jr. Exper. Path., 1943, xxiv, 171-173. Google Scholar24. RICHTERCLISBY CPKH: Graying of hair produced by ingestion of phenylthiocarbamide, Proc. Soc. Exper. Biol. and Med., 1941, xlviii, 684-687. RICHTER, C. P., and CLISBY, K. H.: Toxic effects of bitter-tasting phenylthiocarbamide, Arch. Path., 1942, xxxiii, 46-57. CrossrefGoogle Scholar25. MACKENZIEMACKENZIEMCCOLLUM JBCGEV: Effect of sulfanilylguanidine on the thyroid of the rat, Science, 1941, xciv, 518-519. CrossrefGoogle Scholar26. MACKENZIEMACKENZIE JBCG: The effect of "sulfa" drugs on the thyroid gland in rats and mice, Fed. Proc., 1942, i, 122-123. Google Scholar27. KENNEDY TH: Thioureas as goitrogenic substances, Nature, 1942, cl, 233-234. CrossrefGoogle Scholar28. MACKENZIEMACKENZIE CGJB: Effect of sulfonamides and thioureas on the thyroid gland and basal metabolism, Endocrinology, 1943, xxxii, 185-209. CrossrefGoogle Scholar29. ASTWOODSULLIVANBISSELLTYSLOWITZ EBJAR: Action of certain sulfonamides and of thiourea upon the function of the thyroid gland of the rat, Endocrinology, 1943, xxxii, 210-225. CrossrefGoogle Scholar30. ASTWOOD EB: The chemical nature of compounds which inhibit the function of the thyroid gland, Jr. Pharmacol. and Exper. Therap., 1943, lxxviii, 79-89. Google Scholar31. VANDERLAANBISSELL WPA: Influence of selected goitrogenic compounds on the thyroid gland of the chick, Endocrinology, 1946, xxxviii, 308-314. CrossrefGoogle Scholar32. VANDERLAANVANDERLAAN JEWP: The iodide-concentrating mechanism of the rat thyroid and its inhibition by thiocyanate, Endocrinology, 1947, xl, 403-416. CrossrefGoogle Scholar33. TAUROGCHAIKOFFFELLER AILDD: The mechanism of iodine concentration by the thyroid gland: its non-organic iodine binding capacity in the normal and propylthiouracil-treated rat, Jr. Biol. Chem., 1947, clxxi, 189. CrossrefGoogle Scholar34. VANDERLAANVANDERLAAN JEWP: Unpublished observations, 1947. Google Scholar35. KLEINFARKASS GE: Microchemical detection of alkaloids in plants. XIV. Cytisine, Oesterr. Bot. Ztschr., 1930, lxxix, 107-124. CrossrefGoogle Scholar36. PANSEPARANJPE TBAS: An alkaloidal substance isolated from Carica papaya seeds, Rasayanam, 1941, i, 215-216. Google Scholar37. ASTWOODBISSELL EBA: Effect of thiouracil on the iodine content of the thyroid gland, Endocrinology, 1944, xxxiv, 282-296. CrossrefGoogle Scholar38. ASTWOODBISSELLHUGHES EBAAM: Further studies on the chemical nature of compounds which inhibit the function of the thyroid gland, Endocrinology, 1945, xxxvii, 456-481. CrossrefGoogle Scholar39. ANDERSON GW: Antithyroid compounds. To be published, 1949. Google Scholar40. HUGHESASTWOOD AMEB: Unpublished observations, 1944. Google Scholar41. PERRAULTBOVET MD: Aminothiazole in the treatment of thyrotoxicosis, Lancet, 1946, ccl, 731-734. CrossrefGoogle Scholar42. STANLEYASTWOOD MMEB: Determination of the relative activities of antithyroid compounds in man using radioactive iodine, Endocrinology, 1947, xli, 66-84. CrossrefGoogle Scholar43. STANLEYASTWOOD MMEB: l-Methyl-2-mercaptoimidazole: an antithyroid compound highly active in man, Endocrinology, 1949, xliv. Google Scholar44. GREERASTWOOD MAEB: The antithyroid effect of certain foods in man as determined with radioactive iodine, Endocrinology, 1948, xliii, 105-119. CrossrefGoogle Scholar45. ASTWOODGREERETTLINGER EBMAMG: The antithyroid factor of yellow turnip, Science, 1949, cvii. Google Scholar46. ETTLINGER MG: To be published, 1949. Google Scholar47. HOPKINS CY: A sulfur-containing substance from the seed of Conringia orientalis , Can. Jr. Res., 1938, xvi, 341-344. CrossrefGoogle Scholar48. BASTENIE PA: Diseases of the thyroid gland in occupied Belgium, Lancet, 1947, cclii, 789-791. CrossrefGoogle Scholar49. STANLEYASTWOOD MMEB: The accumulation of radioactive iodide by the thyroid gland in normal and thyrotoxic subjects and the effect of thiocyanate on its discharge, Endocrinology, 1948, xlii, 107-123. CrossrefGoogle Scholar50. REINHOLD G: Ueber Schilddrusentherapie bei Kropfleidenden Geisteskranken, Munchen. med. Wchnschr., 1894, xxi, 613-614. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*John Phillips Memorial Lecture delivered at the Thirtieth Annual Session of the American College of Physicians, New York, N. Y., March 30, 1949.From the Joseph H. Pratt Diagnostic Hospital and the Department of Medicine, Tufts Medical School.The original work included in this review was supported in part by grants from the Committee on Endocrinology of the National Research Council, the American Cyanamid Company, and the United States Public Health Service. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBoron – A potential goiterogen?Scientific report of the Endocrine Active Substances Task ForceEndokrinologie in der KinderheilkundeDie SchilddrüseGoiterTHYROID SECRETION IN HEALTH AND DISEASEThyroiditis in ChildhoodSTUDIES ON EXPERIMENTAL GOITER : IV. EFFECT OF RAPESEED FEEDING ON THE THYROID AND ADRENAL GLANDS OF CHICKENS AND RABBITSDietary Facrors in Endocrinologic Disorders and Hormone TherapyÜber die Chemie der Brassica-Faktoren, ihre Wirkung auf die Funktion der Schilddrüse und ihr Übergehen in die MilchDie SchilddrüsenhormoneREFERENCESAbstracts of CommunicationIodine Prophylaxis of GoitreDEFECTIVE ORGANIC BINDING OF IODINE BY THE THYROID IN HASHIMOTO'S THYROIDITISDie SchilddrüsePhysiology and treatment of myxedemaIODINEPrevention of GoitreInduction of thyroid tumors in rats by a low iodine dietThe Chemistry and Physiology of the ThyroidClinical EndocrinologyENDEMIC GOITER: A PROBLEM IN PREVENTIVE MEDICINE*DAVID MARINE, M.D., F.A.C.P.The Absence of Anti-thyroid Properties for Rats in Two Types of Groundnut Oil in Common Use in NigeriaUntersuchungen �ber die Jodresorption im Bade mit Hilfe von RadiojodA Working Pathologic Classification of Thyroid DiseaseJodThe Cause of Simple GoitreJodstoffwechsel, Schilddr�se und HypophysenvorderlappenA Case of Sporadic Congenital GoitreOUTWORKTASTE SENSITIVITY TO PHENYL THIOUREAERYTHEMA MULTIFORME EXUDATIVUM (THE STEVENS-JOHNSON SYNDROME)TASTE SENSITIVITY TO PHENYLTHIOUREA IN GOITRE AND DIABETES 1 June 1949Volume 30, Issue 6Page: 1087-1103KeywordsDiagnostic medicineEndocrinologyHormone synthesisHospital medicineMedical servicesThyroidThyroid hormones ePublished: 1 December 2008 Issue Published: 1 June 1949 Copyright & PermissionsCopyright, 1949, by The American College of PhysiciansPDF downloadLoading ...