February 1, 1999HypertensionOpen Access

Kidney Aminopeptidase A and Hypertension, Part I

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Why the study?

Does captopril reduce kidney aminopeptidase A activity in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats at 4, 8, and 16 weeks of age

Comparison

Captopril for 2 weeks (in a subset of SHR) vs Normotensive Wistar-Kyoto rats and untreated SHR

Design

Preclinical

Follow-up

2 weeks (for captopril treatment)

Authors

DHDennis P. HealyBayer (United States)LSLijun SongVanderbilt University

Discussion

Member takes

Implication

Supports RAS-APA regulation in SHR models; hypothesis-generating for hypertension therapies, with no clinical implications yet.

Structured PICO

Does captopril reduce kidney aminopeptidase A activity in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats at 4, 8, and 16 weeks of age

Intervention

Captopril for 2 weeks (in a subset of SHR)

Comparator

Normotensive Wistar-Kyoto rats (for baseline comparisons) and untreated SHR (implied for captopril experiment)

Outcome

Tissue and plasma levels of aminopeptidase A (APA)surrogate

Kidney aminopeptidase A expression is upregulated in spontaneously hypertensive rats and is reduced by captopril, suggesting regulation by the renin-angiotensin system.

Cite This Study

Healy et al. (1999) studied this question.

synapsesocial.com/papers/6a7341849549f962dac3fb3f https://doi.org/10.1161/01.hyp.33.2.740

Topics

Hypertension management

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Kidney Aminopeptidase A and Hypertension, Part I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Kidney Aminopeptidase A and Hypertension, Part I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider