A case of central neurofibromatosis

The clinical and pathological features of multiple neurofibromatosis (von Recklinghausen's disease) are usually striking and often rather bizarre. It has hence attracted much interest and is well described and illustrated. Recent accounts include those by Willis (1958) and Russell and Rubinstein (1959); a fuller review in German by Schmincke (1956) is mainly devoted to the description and inter-pretation of the nerve lesions. Of the many earlier reports, that of Preiser and Davenport (1918) retains, perhaps, most of its interest. The disease is characterized by the occurrence of multiple dysplasic and proliferative changes in nerves, the central nervous system and other tissues. The skin is commonly affected, showing patchy