Why the study?
What are the cardiovascular effects of therapeutic doses of tricyclic antidepressants in depressed patients?
Population
Depressed patients with and without cardiovascular disease
Design
Review
Authors
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Requires caution for orthostatic hypotension and heart block in bundle-branch disease; leaves open need for modern RCTs on TCA safety.
What are the cardiovascular effects of therapeutic doses of tricyclic antidepressants in depressed patients?
Therapeutic doses of tricyclic antidepressants are generally safe in depressed patients without cardiovascular disease, but require caution regarding orthostatic hypotension and heart block in specific cardiac populations.
A H Glassman (1984) studied this question.
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