Key result
Among depressed patients on tricyclic antidepressants, second-degree atrioventricular block occurred in 9% of those with preexisting bundle-branch block versus 0.7% of those with normal ECGs.
Why the study?
Do tricyclic antidepressants at therapeutic concentrations increase the risk of cardiovascular complications in depressed patients with preexisting cardiac conduction disease compared to those with normal electrocardiograms?
Population
196 depressed patients, including 155 with normal electrocardiograms and 41 with either prolonged PR…
Comparison
Tricyclic antidepressants at therapeutic plasma… vs Depressed patients with normal…
Design
Cohort
Authors
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Warrants ECG screening and caution with TCAs in patients with bundle-branch block; leaves open need for randomized confirmation.
Cohort (n=196)
Do tricyclic antidepressants at therapeutic concentrations increase the risk of cardiovascular complications in depressed patients with preexisting cardiac conduction disease compared to those with normal electrocardiograms?
Absolute Event Rate: 9% vs 0.7%
Tricyclic antidepressants at therapeutic doses pose a significantly higher risk of second-degree AV block in depressed patients with preexisting bundle-branch block compared to those with normal ECGs.
Steven P. Roose (1987) conducted a cohort in Depression (n=196). Preexisting bundle-branch block and/or prolonged PR interval vs. Normal electrocardiograms was evaluated on Second-degree atrioventricular block. Among depressed patients on tricyclic antidepressants, second-degree atrioventricular block occurred in 9% of those with preexisting bundle-branch block versus 0.7% of those with normal ECGs.
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