Frequent Early Discontinuation of SSRI Prescribed by Primary Care Physicians in Young Males in Japan

OBJECTIVE: In the present study, we tried to clarify the prevalence of selective serotonin reuptake inhibitor (SSRI) prescription and early discontinuation of SSRI in a outpatient unit where primary care physicians are working in Japan. MATERIALS AND METHODS: Consecutive outpatients who newly visited the Department of General Medicine, Asahikawa Medical College Hospital, Asahikawa, Japan between April 2004 and March 2008 were analyzed. Each parameter such as age, sex, diagnosis, period of continuation of SSRI or reason why they discontinued SSRI was investigated. RESULTS: Among 4670 patients, 126 patients (2.7%) had been prescribed SSRI because of depressive state (n=117) or panic disorder (n=9). Female patients with depression received SSRI (84/2714 = 3.10%) more frequently than male patients (33/1956 = 1.69%). Out of 117 patients with depression who had been prescribed SSRI, 28 (23.9%) patients discontinued SSRI within 4 weeks. Male patients (30.5%) discontinued SSRI within 4 weeks due to patient's decision more frequently than female patients (11.1%). The rate of patients who discontinued SSRI within 4 weeks due to patient's decision was particularly high (6/9; 67%) in male patients aged 20 to 29 years. CONCLUSION: These results suggest for the first time that there is a high prevalence of early discontinuation of SSRI in young male patients in Japan.