Why the study?
Do fentanyl and sufentanil alter action potential parameters in isolated canine cardiac Purkinje fibers?
Population
Isolated canine cardiac Purkinje fibers
Design
Preclinical
Authors
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May warrant caution with high-dose regimens in vulnerable patients; leaves open translation to human myocardium and clinical arrhythmias.
Do fentanyl and sufentanil alter action potential parameters in isolated canine cardiac Purkinje fibers?
High concentrations of fentanyl and sufentanil prolong action potential duration in canine cardiac Purkinje fibers via direct membrane actions rather than opioid receptor interaction.
Blair et al. (1989) studied this question.
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