July 1, 1995Journal of Cardiovascular Pharmacology

Electrophysiological Demonstration and Activation of μ-Opioid Receptors in the Rabbit Sinoatrial Node

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Population

Small preparations (0.2 x 0.2 x 0.1 mm) of rabbit sinoatrial (SA) node (SAN)

Comparison

Fentanyl citrate (0.1–3 μM) vs Baseline and opioid receptor antagonists

Design

Preclinical

Authors

TSTomoaki SaekiFujita Health University MNMasao NishimuraKanazawa University NSNobuyuki SatoAsahikawa Medical University

Discussion

Member takes

Implication

May contribute to fentanyl-associated bradycardia; leaves open human sinoatrial node translation and clinical relevance.

Structured PICO

Population

Small preparations (0.2 x 0.2 x 0.1 mm) of rabbit sinoatrial (SA) node (SAN)

Intervention

Fentanyl citrate (0.1–3 μM)

Comparator

Baseline (control) and opioid receptor antagonists (β-funaltrexamine, nor-binaltorphimine, ICI-174864)

Outcome

Changes in spontaneous action potential (AP) parameters and membrane currentssurrogate

Activation of μ-opioid receptors by fentanyl in rabbit sinoatrial node cells exerts a negative chronotropic action by decreasing the conductance of multiple membrane currents.

Cite This Study

Saeki et al. (1995) studied this question.

synapsesocial.com/papers/6a90e285504d7cdc493e78e8 https://doi.org/10.1097/00005344-199507000-00025

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