Key result
Glucagon-like peptide-1-based therapies may have beneficial effects on cardiovascular risk factors, atherogenesis, ischaemic heart disease, and heart failure in patients with diabetes.
Why the study?
Do GLP-1-based therapies improve cardiovascular outcomes in patients with diabetes mellitus?
Do GLP-1-based therapies improve cardiovascular outcomes in patients with diabetes mellitus?
GLP-1-based therapies show potential beneficial effects across the cardiovascular continuum in diabetes, highlighting the need for large-scale clinical trials to confirm cardiovascular outcome improvements.
Hypothesis-generating for CV effects in diabetes; large RCTs needed before practice change.
AIMS: Glucagon-like peptide-1 receptor agonists and inhibitors of dipeptidyl peptidase-4 that increase glucagon-like peptide-1 plasma concentrations are current treatment options for patients with diabetes mellitus. As patients with diabetes are a high-risk population for the development of a severe and diffuse atherosclerosis, we aim to review the potential action of these drugs on cardiovascular disease and to summarize the potential role of present glucagon-like peptide-1-based therapies from a cardiologist's point of view. METHODS: Using a PubMed/MEDLINE search without language restriction, studies were identified and evaluated in order to review the effects of glucagon-like peptide-1-based therapy on different stages of the cardiovascular continuum. RESULTS: Recent experimental as well as clinical data suggest that dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists--in addition to their metabolic effects--may have beneficial effects on the cardiovascular continuum at multiple stages, including: (1) cardiovascular risk factors; (2) molecular mechanisms involved in atherogenesis; (3) ischaemic heart disease; and (4) heart failure. Furthermore, retrospective analysis suggested decreased cardiovascular events in patients with glucagon-like peptide-1-based therapies. CONCLUSION: There are ample data to suggest beneficial effects of glucagon-like peptide-1-based therapies on the cardiovascular continuum and large-scale clinical trials are warranted to determine whether these effects translate into improved cardiovascular endpoints in humans.
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Burgmaier et al. (2012) conducted a review in diabetes mellitus. Glucagon-like peptide-1-based therapies was evaluated. Glucagon-like peptide-1-based therapies may have beneficial effects on cardiovascular risk factors, atherogenesis, ischaemic heart disease, and heart failure in patients with diabetes.
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