August 25, 2011Angiology
Arterial Ultrasound Screening as a Tool for Coronary Risk Assessment in Asymptomatic Men and Women
Key result
Arterial ultrasound abnormalities significantly increased the risk of incident coronary events, with hazard ratios ranging from 2.35 to 14.83 depending on the number of abnormalities.
Why the study?
Does carotid and femoral Doppler ultrasonography screening predict incident coronary events in asymptomatic individuals with no history of cardiovascular disease?
Population
2709 asymptomatic men and women with no history or symptoms of cardiovascular disease
Design
Cohort
Follow-up
median 6 years
Authors
Discussion
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Implication
May aid risk stratification in asymptomatic patients; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=2,709)
Structured PICO
Does carotid and femoral Doppler ultrasonography screening predict incident coronary events in asymptomatic individuals with no history of cardiovascular disease?
P
Population
2,709 participants with no history or symptoms of cardiovascular disease, followed for a median of 6 years.
E
Exposure
Carotid and femoral Doppler ultrasonography screening (assessing for carotid stenosis >50%, carotid plaque, femoral plaque, and increased intima-media thickness)
O
Outcome
Incident cases of definite coronary eventshard clinical
Main Result
Effect estimate: HR 2.35 to 14.83 (95% CI 1.16-4.74 to 6.47-33.9)
Carotid and femoral ultrasound screening identifies asymptomatic individuals at significantly increased risk for future coronary events based on the burden of arterial abnormalities.
Cite This Study
Cournot et al. (2011) conducted a cohort in No history or symptoms of cardiovascular disease (n=2,709). Arterial ultrasound abnormalities (carotid/femoral plaque, increased IMT, stenosis) vs. Fewer or no ultrasound abnormalities was evaluated on Incident cases of definite coronary events (HR 2.35 to 14.83, 95% CI 1.16-4.74 to 6.47-33.9). Arterial ultrasound abnormalities significantly increased the risk of incident coronary events, with hazard ratios ranging from 2.35 to 14.83 depending on the number of abnormalities.