Key result
In a network meta-analysis of 93 RCTs (N=32,404), there was insufficient evidence to suggest first-line antihypertensive medications reduced blood pressure significantly more than exercise.
Why the study?
The comparative efficacy of anti-hypertensive medications versus exercise interventions on systolic and diastolic blood pressure reduction in people with hypertension was unknown.
Do anti-hypertensive medications or exercise interventions reduce blood pressure more effectively in people with hypertension?
Population
32,404 people with hypertension across 93 RCTs
Comparison
Exercise interventions vs first-line antihypertensive medications vs placebo or usual care
Design
Systematic review and network meta-analysis of RCTs
Authors
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Exercise may rival antihypertensives for BP lowering; challenges medication-first guidelines and supports direct comparative trials.
Meta-Analysis (n=32,404)
Do anti-hypertensive medications or exercise interventions reduce blood pressure more effectively in people with hypertension?
While anti-hypertensive medications rank higher for blood pressure reduction, exercise remains a viable alternative for low-risk hypertension patients given the lack of significant difference in efficacy.
Noone et al. (2019) conducted a meta-analysis in Hypertension (n=32,404). First-line antihypertensive medications and exercise interventions vs. Placebo or usual care was evaluated on Systolic and diastolic blood pressure reduction. In a network meta-analysis of 93 RCTs (N=32,404), there was insufficient evidence to suggest first-line antihypertensive medications reduced blood pressure significantly more than exercise.
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