Key result
A positive family history of coronary artery disease was independently associated with impaired endothelium-dependent coronary blood flow responses to acetylcholine (P=0.008).
Why the study?
Is a positive family history of premature coronary artery disease associated with impaired endothelium-dependent coronary blood flow regulation in patients with normal or minimally diseased coronary vessels?
Cross-Sectional (n=150)
Is a positive family history of premature coronary artery disease associated with impaired endothelium-dependent coronary blood flow regulation in patients with normal or minimally diseased coronary vessels?
p-value: p=0.030
A positive family history of premature coronary artery disease is an independent predictor of impaired endothelium-dependent coronary blood flow regulation, aggravating dysfunction associated with age and hypercholesterolemia.
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May flag higher-risk patients for closer surveillance; leaves open causal links and preventive interventions.
Schächinger et al. (1999) conducted a cross-sectional in Angiographically normal or minimally diseased coronary vessels (n=150). Positive family history of coronary artery disease vs. No positive family history of coronary artery disease was evaluated on Coronary blood flow responses to acetylcholine (p=0.030). A positive family history of coronary artery disease was independently associated with impaired endothelium-dependent coronary blood flow responses to acetylcholine (P=0.008).
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