Key result
Family history of premature CAD linked to ~31% lower FMD in young healthy subjects.
Why the study?
The study was conducted to assess endothelial dysfunction in young healthy first-degree relatives with a family history of premature coronary artery disease using vascular Doppler ultrasonography.
Does vascular doppler ultrasonography detect impaired flow-mediated dilatation in young healthy first-degree relatives of patients with premature CAD compared to healthy controls?
Case-Control (n=60)
No
Does vascular doppler ultrasonography detect impaired flow-mediated dilatation in young healthy first-degree relatives of patients with premature CAD compared to healthy controls?
Absolute Event Rate: 8.42% vs 12.22%
p-value: p=<0.05
Young, healthy first-degree relatives of patients with premature CAD exhibit impaired endothelial function, suggesting vascular Doppler ultrasonography could serve as a non-invasive screening tool for subclinical atherosclerosis.
Impaired FMD associated with family history of premature CAD; leaves open whether vascular ultrasound aids early risk stratification in relatives.
Background: Endothelial dysfunction in young healthy first-degree relatives with family history of premature coronary artery disease was assessed in the present study using vascular doppler ultrasonography.Methods: Thirty young (10-40 years) first degree relatives of 17 patients with premature CAD without risk factors were selected for the study. Age and gender matched healthy subjects were enrolled as controls. Non- invasive assessment of endothelial dysfunction was done by vascular doppler study of brachial artery. Brachial artery diameter, velocity and blood flow were estimated in every study subject and control at rest, after stress and again at rest and after glyceryl-trinitrate (GTN) by vascular Doppler ultrasonography.Results: The percent rise in lumen diameter of brachial artery after stress i.e. reactive hyperaemia, labelled as percent rise in flow mediated dilatation (FMD), was significantly lower in family history group than in controls (8.42±3.47% vs 12.22±4.31%, p<0.05). The statistically significant difference in percent rise in FMD was observed to be consistent across different ages/genders (p<0.05). The mean percent rise in FMD among family history group with positive maternal history (8.06±3.65) was lower as compared to those with positive paternal history (8.57±3.12), but the difference was not statistically significant (p>0.05).Conclusions: Apparently healthy young subjects with family history of premature CAD have impaired endothelium dependent FMD in systemic circulation. Simple, non-invasive, cost-effective vascular doppler ultrasonography is recommended as a potential screening tool to detect subclinical atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Khandait et al. (2019) conducted a case-control in Family history of premature coronary artery disease (n=60). Family history of premature coronary artery disease vs. Healthy subjects without family history of premature CAD was evaluated on Percent rise in flow mediated dilatation (FMD) (p=<0.05). Young healthy subjects with a family history of premature coronary artery disease had significantly lower flow-mediated dilatation compared to matched controls (8.42% vs 12.22%, p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: