Key result
Coronary risk factors linked to ~28% lower flow-mediated dilatation versus healthy controls.
Why the study?
Does the accumulation of coronary risk factors reduce endothelium-dependent flow-mediated dilatation of the brachial artery in subjects without clinical atherosclerosis?
Population
141 subjects without clinical atherosclerosis, comprising 101 subjects with one or more coronary risk…
Comparison
Presence of one or more coronary risk factors vs Absence of coronary risk factors
Design
Cross-sectional
Authors
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May signal early endothelial impairment before atherosclerosis; hypothesis-generating for FMD utility in primary prevention cohorts.
Cross-Sectional (n=141)
Single-blind
No
Does the accumulation of coronary risk factors reduce endothelium-dependent flow-mediated dilatation of the brachial artery in subjects without clinical atherosclerosis?
Absolute Event Rate: 4.8% vs 6.7%
p-value: p=<0.01
The accumulation of coronary risk factors is significantly associated with impaired endothelial function, as measured by flow-mediated dilatation, even before the development of clinical atherosclerosis.
Hashimoto et al. (2000) conducted a cross-sectional in Coronary risk factors without clinical atherosclerosis (n=141). Presence of one or more coronary risk factors vs. Subjects without coronary risk factors was evaluated on Percentage change in flow-mediated diameter (%FMD) (p=<0.01). The presence of one or more coronary risk factors was associated with significantly lower endothelium-dependent flow-mediated dilatation compared to healthy controls (4.8% vs. 6.7%, p<0.01).
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