Key result
Impaired flow-mediated dilatation of the brachial artery is associated with cardiovascular risk factors, but its ability to predict coronary artery disease requires further investigation.
Why the study?
Does impaired flow-mediated dilatation of the brachial artery predict cardiovascular events?
Does impaired flow-mediated dilatation of the brachial artery predict cardiovascular events?
The clinical utility of brachial artery flow-mediated dilatation as an independent predictor of coronary artery disease remains uncertain and warrants further investigation.
May indicate CV risk via impaired FMD; leaves open its predictive value for CAD pending further study.
Endothelial dysfunction is thought to be an important factor in the development of atherosclerosis. Over the past decade, a non-invasive technique has evolved to evaluate flow-mediated vasodilation (FMD), an endothelium-dependent function, in the brachial artery. FMD decreases with increasing age and subjects with diabetes mellitus, hypercholesterolemia, smokers and hypertension have decreased FMD. There are a few concise studies reporting that FMD predicts cardiovascular events. However, the assumption that focal measurement of brachial artery FMD predicts coronary artery disease deserves further investigation. Keywords: flow-mediated dilatation, brachial artery, cardiovascular risk factor?, flow-mediated vasodilation, hypercholesterolemia, coronary artery disease
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Stefan Agewall (2003) conducted a review in Cardiovascular risk. Impaired flow-mediated dilatation (FMD) of the brachial artery was evaluated on Cardiovascular events. Impaired flow-mediated dilatation of the brachial artery is associated with cardiovascular risk factors, but its ability to predict coronary artery disease requires further investigation.
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