Key result
Acute ischemic stroke and chronic heart failure were associated with similarly decreased peripheral endothelial function compared to healthy controls (RHI 1.8 vs 1.8 vs 2.2, p=0.01).
Population
129 patients: 60 with acute stroke in the territory of the middle cerebral artery, 23 negative controls, and…
Design
Cross-sectional
Authors
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Should not yet change practice in stroke or HF; hypothesis-generating for shared endothelial pathways.
Observational (n=129)
Absolute Event Rate: 1.8% vs 2.2%
p-value: p=0.01
Peripheral endothelial dysfunction occurs to a similar degree in acute ischemic stroke and chronic heart failure, potentially mediated by asymmetric dimethylarginine (ADMA).
Scherbakov et al. (2011) conducted an observational in Acute ischemic stroke (n=129). Acute ischemic stroke vs. Healthy controls and patients with chronic heart failure was evaluated on Reactive hyperemia index (RHI) (p=0.01). Acute ischemic stroke and chronic heart failure were associated with similarly decreased peripheral endothelial function compared to healthy controls (RHI 1.8 vs 1.8 vs 2.2, p=0.01).
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