What question did this study set out to answer?

To compare the hemodynamic stability and plasma renin activity changes associated with sodium nitroprusside, nitroglycerin, and adenosine during controlled hypotension and subsequent hemorrhagic shock.

January 1, 1985Acta Anaesthesiologica Scandinavica

Renin Release during Controlled Hypotension with Sodium Nitroprusside, Nitroglycerin and Adenosine: A Comparative Study in the Dog

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Authors

MLMichael LagerkranserKarolinska Institutet ASAlf SolleviUniversidad Mayor LIL. IrestedtKarolinska Institutet

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Implication

Animal data on vasodilator effects during hypotension and hemorrhage should not guide practice; leaves open differential renin responses in humans.

Key Points

To compare the hemodynamic stability and plasma renin activity changes associated with sodium nitroprusside, nitroglycerin, and adenosine during controlled hypotension and subsequent hemorrhagic shock.
Infused dogs intravenously with sodium nitroprusside, nitroglycerin, or adenosine to lower mean arterial blood pressure to a target of approximately 50 mmHg (6.7 kPa).
Measured plasma renin activity at 10-minute intervals via radioimmunoassay, ending with an induced hemorrhagic shock challenge.
Sodium nitroprusside required dose increases from 11.8 to 16.0 µg·kg⁻¹·min⁻¹ (P < 0.05) to sustain hypotension, while nitroglycerin achieved only 60 to 80 mmHg; both caused blood pressure-dependent increases in plasma renin activity that intensified during hemorrhagic shock.
Adenosine maintained a stable target blood pressure without dose adjustments and completely prevented increases in plasma renin activity, even during hemorrhagic shock.

Cite This Study

Lagerkranser et al. (1985) studied this question.

synapsesocial.com/papers/6a734f2129b0f29a5dc67a78 https://doi.org/10.1111/j.1399-6576.1985.tb02157.x

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Implication

Animal data on vasodilator effects during hypotension and hemorrhage should not guide practice; leaves open differential renin responses in humans.

Renin Release during Controlled Hypotension with Sodium Nitroprusside, Nitroglycerin and Adenosine: A Comparative Study in the Dog

Discussion

Member takes

Implication

Key Points

Cite This Study

Renin Release during Controlled Hypotension with Sodium Nitroprusside, Nitroglycerin and Adenosine: A Comparative Study in the Dog

Discussion

Member takes

Implication

Key Points

Cite This Study

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