March 1, 2001AJP Cell PhysiologyOpen Access

Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy

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Why the study?

Does a null mutation in the IIb MyHC gene affect muscle growth and morphology in mice?

Structured PICO

Does a null mutation in the IIb MyHC gene affect muscle growth and morphology in mice?

Population

Mice (wild type and those with a null mutation in the IIb myosin heavy chain gene)

Intervention

Null mutation in the IIb myosin heavy chain (MyHC) gene

Comparator

Wild type mice

Outcome

Growth and morphology of mouse skeletal muscle (muscle mass, mean fiber number, mean cross-sectional area, fiber pathology)surrogate

Loss of the major MyHC isoform produces fiber loss and pathology reminiscent of muscle disease, along with compensatory hypertrophy.

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IIb MyHC loss induces fiber pathology in mice; hypothesis-generating for human myopathies, translation remains open.

Allen et al. (2001) studied this question.

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