January 1, 2000Microscopy Research and Technique

Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes

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Population

Mice null for four different Myosin heavy chain isoforms

Comparison

Inactivation of specific MyHC genes vs Wild type mice

Design

Review

Authors

DADavid L. AllenTexas Children's Hospital BHBrooke C. HarrisonBoston College LLLeslie A. LeinwandBoston University

Discussion

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Implication

Does not alter clinical practice; extends preclinical evidence that MyHC isoforms have unique non-redundant roles in muscle.

Structured PICO

Population

Mice null for four different Myosin heavy chain (MyHC) isoforms (nonmuscle II-B, alpha cardiac MyHC, IIb or IId adult skeletal MyHC)

Intervention

Inactivation of specific MyHC genes (null mutations)

Comparator

Wild type mice

Outcome

Phenotypic abnormalities including cardiac defects, skeletal muscle pathology, body/muscle mass, and contractile functionsurrogate

This review of preclinical models demonstrates that different myosin heavy chain isoforms have unique, non-redundant roles in cardiac and skeletal muscle function.

Cite This Study

Allen et al. (2000) studied this question.

synapsesocial.com/papers/6a727cef35aa2c282ce3477d https://doi.org/10.1002/1097-0029(20000915)50:6<492::aid-jemt6>3.0.co;2-j

View Full Paper

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Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider