Why the study?
Does the ablation of nonmuscle myosin heavy chain B (NMHC-B) affect cardiac development and survival in mice?
Does the ablation of nonmuscle myosin heavy chain B (NMHC-B) affect cardiac development and survival in mice?
Nonmuscle myosin II-B is required for normal cardiac myocyte development, and its absence leads to structural defects resembling tetralogy of Fallot and double outlet right ventricle.
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NMHC-B ablation disrupts murine cardiac development; leaves open its role in human congenital heart defects.
Tullio et al. (1997) studied this question.
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