Population
Mice ablated for NMHC II-A and wild-type embryonic stem cells
Comparison
Ablation of NMHC II-A or introduction of siRNA… vs Wild-type mice/cells
Design
Preclinical
Authors
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No immediate clinical implications from this mouse model; leaves open NMHC II-A roles in later cardiac or human development.
NMHC II-A plays an essential role in maintaining cell-cell adhesions in the early mammalian embryo.
Conti et al. (2004) studied this question.
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