March 1, 2000Journal of Clinical InvestigationOpen Access

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

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Population

Mice with genetically decreased amounts of nonmuscle myosin heavy chain II-B, specifically B/B and B/B models.

Comparison

Genetic reduction of NMHC-B via replacement of a… vs Wild-type B(+)/B(+) mice.

Design

Preclinical

Follow-up

Up to 11 months

Authors

DÜDeniz ÜrenNational Institutes of Health HHHweung-Kon HwangNational Heart Lung and Blood Institute YHYoshinobu HaraKitasato University

Discussion

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Implication

No immediate clinical implications; hypothesis-generating for myosin II-B gene dosage in human cardiac development.

Structured PICO

Population

Mice with genetically decreased amounts of nonmuscle myosin heavy chain II-B (NMHC-B), specifically B(DeltaI)/B(DeltaI) and B(DeltaI)/B(-) models.

Intervention

Genetic reduction of NMHC-B via replacement of a neural-specific alternative exon with a PGK-Neo cassette (B(DeltaI)/B(DeltaI)) and crossing with B(+)/B(-) mice to generate B(DeltaI)/B(-) mice.

Comparator

Wild-type B(+)/B(+) mice.

Outcome

Cardiac and brain developmental defects, specifically cardiac myocyte hypertrophy, ventricular septal defects, and hydrocephalus.

The study demonstrates a gene dosage effect of nonmuscle myosin heavy chain II-B on the severity and time of onset of cardiac and brain developmental defects in mice.

Cite This Study

Üren et al. (2000) studied this question.

synapsesocial.com/papers/6a9058cb6e7e048e0989d613 https://doi.org/10.1172/jci8199

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Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B–depleted mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider