Isoproterenol may be an effective rescue therapy for epinephrine-resistant anaphylactic shock and severe bradycardia in children on beta-blockers.
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May support isoproterenol rescue in beta-blocked children with epinephrine-resistant anaphylactic bradycardia; hypothesis-generating case leaves role unconfirmed.
Like adults, children taking beta-blockers are at risk for serious hemodynamic instability in case of anaphylaxis. We report a case of severe bradycardia associated with anaphylactic shock after aprotinin in a beta-blocked child, which was resistant to intravenous epinephrine and vascular filling but was treated successfully with isoproterenol.
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Momeni et al. (2007) studied this question.
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