Key result
Ascent to high-altitude reduced sympathetically mediated blood pressure regulation, and Andean natives showed reduced blood pressure responsiveness to sympathetic nervous activity compared with Sherpas.
Why the study?
Does high altitude exposure and adaptation alter sympathetically mediated blood pressure regulation?
Observational
Does high altitude exposure and adaptation alter sympathetically mediated blood pressure regulation?
High altitude acclimatization and adaptation alter sympathetically mediated blood pressure regulation, providing a foundation for understanding blood pressure control under persistent hypoxia.
Blunted sympathetic blood pressure regulation at high altitude warrants clinical caution during ascent; leaves open mechanisms of ethnic adaptation and SNA-BP coupling.
This study has identified that sympathetically mediated blood pressure regulation is reduced following ascent to high-altitude. Additionally, we show that high altitude Andean natives have reduced blood pressure responsiveness to sympathetic nervous activity (SNA) compared with Nepalese Sherpa. However, basal sympathetic activity is inversely related to the magnitude of SNA-mediated fluctuations in blood pressure regardless of population or condition. These data set a foundation to explore more precise mechanisms of blood pressure control under conditions of persistent sympathetic activation and hypoxia.
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Berthelsen et al. (2020) conducted an observational in High altitude exposure and hypoxia. High altitude ascent and adaptation vs. Baseline / Nepalese Sherpa was evaluated on Sympathetically mediated blood pressure regulation. Ascent to high-altitude reduced sympathetically mediated blood pressure regulation, and Andean natives showed reduced blood pressure responsiveness to sympathetic nervous activity compared with Sherpas.
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