Key result
The length and proximal extent of arterial occlusion dictate the severity of peripheral artery disease across mild, moderate, and severe phenotypes in an Ossabaw mini-swine model.
Why the study?
There is an ongoing need for large animal models of peripheral artery disease (PAD) that replicate human disease.
This study presents an Ossabaw mini-swine model of PAD that can replicate mild, moderate, and severe human disease phenotypes based on occlusion characteristics.
New Ossabaw mini-swine PAD phenotypes extend preclinical options; leaves open human translation and should not change practice.
There is ongoing need for large animal models of peripheral artery disease (PAD) that replicate human disease. We present mild (MI), moderate (MD) and Severe (S) phenotypes of PAD in an Ossabaw mini-swine platform.
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Hakim et al. (2024) studied this question. The length and proximal extent of arterial occlusion dictate the severity of peripheral artery disease across mild, moderate, and severe phenotypes in an Ossabaw mini-swine model.
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