Key result
Hypertension was the only isolated vascular disease significantly associated with arteriosclerosis (OR 2.73; 95% CI 2.46-3.04), largely explaining the associations seen with other diseases.
Why the study?
Carotid femoral pulse wave velocity is associated with vascular-related diseases, but this association has rarely been compared across diseases within the same population.
What is the association between different vascular-related diseases and arteriosclerosis (measured by carotid femoral pulse wave velocity)?
Observational (n=13,798)
What is the association between different vascular-related diseases and arteriosclerosis (measured by carotid femoral pulse wave velocity)?
Odds Ratio: 2.73 (95% CI 2.46–3.04)
p-value: p=<.001
Hypertension appears to be the primary driver of arteriosclerosis (measured by CF-PWV) among various vascular-related diseases, as associations with other diseases are largely explained by coexisting hypertension.
AIMS: Carotid femoral pulse wave velocity (CF-PWV) is associated with vascular-related diseases. However, this association has rarely been compared in the same study population, which would improve our understanding of the role of these diseases in developing arteriosclerosis. This study was designed to assess arterial function in different vascular-related diseases and the potential interrelationships between these diseases and arteriosclerosis. METHODS: There were 13 798 participants with or without established vascular-related diseases, including hypertension, diabetes, coronary artery disease (CAD), stroke and peripheral artery disease (PAD), enrolled into the study from 2010 to 2016, comprising 6648 males and 7150 females. The odds ratio (OR) of arteriosclerosis (defined as CF-PWV >12 m/s) in associations with the vascular-related diseases was modelled using multivariable logistic regression analyses to adjust for possible confounders. RESULTS: Compared with participants without vascular-related diseases, those presenting the diseases showed a significantly higher prevalence and age- and sex-adjusted OR of arteriosclerosis (all P < .001). After further adjustment for hypertension, the ORs became much smaller and not significant for CAD or stroke. Compared with apparently healthy participants, participants with each of the diseases showed a significantly higher adjusted OR (range: 2.46-3.30, all P < .001); participants with each vascular-related disease only showed much smaller and non-significant ORs, except for hypertension (OR = 2.73, 95% CI: 2.46, 3.04). After further adjustment for hypertension, these ORs became non-significant (range: 0.81-1.36, all P > .05). CONCLUSIONS AND CLINICAL IMPLICATIONS: The associations between arteriosclerosis and diseases other than hypertension were largely explained by the association with hypertension, indicating that hypertension could be the single most important factor that leads to arteriosclerosis. TRIAL REGISTRATION: ClinicalTrials.gov NCT02569268.
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Liu et al. (2019) conducted an observational in Vascular-related diseases and arteriosclerosis (n=13,798). Hypertension (and other vascular-related diseases) vs. Apparently healthy participants without vascular-related diseases was evaluated on Arteriosclerosis (defined as CF-PWV >12 m/s) (OR 2.73, 95% CI 2.46-3.04, p=<.001). Hypertension was the only isolated vascular disease significantly associated with arteriosclerosis (OR 2.73; 95% CI 2.46-3.04), largely explaining the associations seen with other diseases.
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