Key result
The automated Sysmex CS-2100i showed excellent repeatability and strong correlation with the Chrono-log 700 for platelet aggregation, with a threshold limitation of platelet counts of 80 × 10^9/L.
Why the study?
Does the automated platelet aggregation method on Sysmex CS-2100i perform comparably to the reference Chrono-log Model 700 aggregometer?
Does the automated platelet aggregation method on Sysmex CS-2100i perform comparably to the reference Chrono-log Model 700 aggregometer?
The automated Sysmex CS-2100i provides a reliable, highly standardized, and less labor-intensive alternative to traditional light transmission aggregometry for platelet function assessment.
Supports automated platelet aggregation testing in labs; leaves open reliability below 80 × 10^9/L.
Light transmission aggregometry (LTA) is the “gold standard” for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex CS-2100i). In this study, the performances of CS-2100i including repeatability, correlation with a reference aggregometer (Chrono-log Model 700), and the threshold limitation of platelet counts in platelet-rich plasma (PRP) were evaluated for clinical use. The agonists were adenosine diphosphate (ADP), arachidonic acid, collagen, epinephrine, and ristocetin. The platelet concentration of PRP was adjusted with platelet-poor plasma (PPP) and physiological saline (PS). The CS-2100i showed an excellent repeatability and a strong correlation with the Chrono-log 700 in performing platelet aggregation, and its threshold limitation of platelet counts in PRP was 80 × 109/L. PPP had an inhibitory impact on platelet aggregation induced by ADP, arachidonic acid, collagen or epinephrine; while PS had an inhibitory impact on ristocetin-induced aggregation. PS should be used to adjust PRP for ADP-, arachidonic acid-, collagen-, or epinephrine-induced aggregation; while PPP was recommended for ristocetin-induced aggregation. The CS-2100i showed an excellent repeatability, a strong correlation with Chrono-log 700, a lower platelet count requirement, a shorter turnaround time for samples, the advantage of being a walk-away technology, and the ability to perform a highly standardized platelet function assessment.
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Ling et al. (2017) studied Platelet function assessment. Automated platelet aggregation method (Sysmex CS-2100i) vs. Chrono-log Model 700 was evaluated on Repeatability, correlation with reference aggregometer, and threshold limitation of platelet counts. The automated Sysmex CS-2100i showed excellent repeatability and strong correlation with the Chrono-log 700 for platelet aggregation, with a threshold limitation of platelet counts of 80 × 10^9/L.
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