Key result
The rs10830963 variant in the MTNR1B gene was associated with an increased risk of incident myocardial infarction among patients with type 2 diabetes.
Why the study?
The MTNR1B variant rs10830963 associates with risk of T2D, but its association with myocardial infarction risk among T2D patients needed examination.
Does the rs10830963 variant in the MTNR1B gene increase the risk of myocardial infarction in patients with type 2 diabetes?
Cohort (n=13,655)
Does the rs10830963 variant in the MTNR1B gene increase the risk of myocardial infarction in patients with type 2 diabetes?
The rs10830963 polymorphism in the MTNR1B gene is associated with an increased risk of myocardial infarction in patients with type 2 diabetes, suggesting its potential as a genetic marker for risk stratification.
Answers are grounded in this paper and cite their sources.
rs10830963 may signal higher MI risk in T2D; extends genetic links observationally but leaves causal role and clinical utility open.
OBJECTIVE The common MTNR1B single nucleotide polymorphism rs10830963 associates with risk of type 2 diabetes (T2D). Here, we examine the association between this gene variant and the risk of myocardial infarction (MCI) among patients with T2D. MCI is a main cause of death and disability among such individuals. RESEARCH DESIGN AND METHODS Data from the UK Biobank cohort were used in order to examine the association between rs10830963 and incidence of MCI (fatal and nonfatal) among 13,655 participants with probable T2D during a follow-up period of 6.8 years. RESULTS Assuming an additive genetic model, a positive association was found between the rs10830963 variant in the MTNR1B gene and the risk for incident MCI during the 6.8-year follow-up (adjusted hazard ratio per G allele 1.19 [95% CI 1.02, 1.40], P = 0.03). CONCLUSIONS The rs10830963 polymorphism may be a useful genetic marker for MCI in patients with T2D.
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Tan et al. (2020) conducted a cohort in Type 2 diabetes (n=13,655). rs10830963 variant in the MTNR1B gene was evaluated on Incidence of myocardial infarction (fatal and nonfatal) (HR 1.19, 95% CI 1.02, 1.40, p=0.03). The rs10830963 variant in the MTNR1B gene was associated with an increased risk of incident myocardial infarction among patients with type 2 diabetes.
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