Population
35 patients with coronary heart disease verified by coronary angiography and healthy controls.
Design
Case-control
Authors
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May explain mood disturbances in CHD via immune-driven tryptophan depletion; hypothesis-generating and needs prospective confirmation.
Immune activation in coronary heart disease is associated with increased tryptophan degradation, which may provide a mechanistic link to mood disturbances and depression in these patients.
Wirleitner et al. (2003) studied this question.
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