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April 1, 1993British Journal of PharmacologyOpen Access

The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea‐pig peritoneal macrophages

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Population

Peritoneal macrophages from horse-serum pretreated guinea-pigs

Design

Preclinical

Authors

NTNicholas C. TurnerUniversité Paris-SudLWLorna WoodAuburn UniversityFBFiona BurnsUniversity College London

Discussion

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Overview

PDE IV and CaM-stimulated isoforms may regulate macrophage superoxide in this model; hypothesis-generating with no clinical implications yet.

Structured PICO

P
Population
Peritoneal macrophages from horse-serum pretreated guinea-pigs
I
Intervention
Selective and non-selective inhibitors of cyclic AMP and cyclic GMP phosphodiesterases (including IBMX, zaprinast, rolipram, Ro20-1724, SK&F 94120, SK&F 94836)
O
Outcome
Superoxide generation (spontaneous and FMLP-stimulated) and cyclic nucleotide phosphodiesterase (PDE) activitysurrogate

Guinea-pig peritoneal macrophages contain predominantly membrane-associated type IV cAMP PDE and cytosolic calcium/calmodulin-stimulated cAMP PDE, both of which regulate spontaneous superoxide generation.

Cite This Study

Turner et al. (1993) studied this question.

synapsesocial.com/papers/6a735835294a46cc7b2c201dhttps://doi.org/10.1111/j.1476-5381.1993.tb13481.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan‐stimulated respiratory burst by ‘type IV’‐selective PDE inhibitors1991 · 142 citations
  2. 2The role of agonists that activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes.1980 · 90 citations
  3. 3Inhibitory action of elevated levels of adenosine-3':5' cyclic monophosphate on phagocytosis: effects on macrophage-Trypanosoma cruzi interaction.1982 · 48 citations